Procoagulant activity in normal human urine associated with subcellular particles

Monocyte procoagulant activity in glomerulonephritis associated with systemic lupus erythematosus.

Monocyte infiltration and activation of the coagulation system have been implicated in the pathophysiology of glomerulonephritis. In this study, spontaneous procoagulant activity (PCA) was measured in circulating mononuclear cells to determine whether elevated PCA correlated with the presence of proliferative glomerulonephritis in patients with systemic lupus erythematosus (SLE). No increase in...

Characterization of Antibodies in Normal Human Urine.

Certain of the physiochemical and immunochemical properties of the y-globulins of normal human urine have been reported by Webb, Rose, and Sehon (2) and by Franklin (3). These urinary proteins were found to be electrophoretically and antigenically closely related to serum y-globulins, but smaller in size; their molecular weights ranged from 10,600 (2) to 38,000 (3). Sedimentation coefficients S...

Procoagulant activity in gastroenterology.

Proteins associated with purified human cytomegalovirus particles.

Virion-associated proteins isolated from purified human cytomegalovirus particles (strain AD169) were used as substrates for chemical sequence analysis. Extracellular virions, noninfectious enveloped particles, and dense bodies were purified by negative viscosity-positive density gradient centrifugation, and their component proteins were separated by denaturing polyacrylamide gel electrophoresi...

The procoagulant potential of environmental particles (PM10).

BACKGROUND AND AIMS Epidemiology studies have shown that cardiovascular (CV) disease is primarily responsible for the mortality associated with increased pulmonary environmental particle (PM10) exposure. The mechanisms involved in PM10 mediated CV effects are unknown although changes in plasma viscosity and in the homoeostasis of blood coagulation have been implicated. It was hypothesised that ...